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KMID : 1036420120050010001
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대한치의학회 영문학회지
2012 Volume.5 No. 1 p.1 ~ p.6
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Overview of Gingival Overgrowth in Transplant Patients
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Park Seo-Jin
Park Jun-Beom
Ko Young-Kyung
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Abstract
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Patients with gingival overgrowth are easily seen in dental clinics. Cyclosporin-A (CsA), a widely prescribed immunosuppressant induces gingival overgrowth in up to 35% of patients with medical history of organ transplantation. The immunosuppressant CsA can transform genetic expression of gingival fibroblasts, resulting in gingival overgrowth. Meticulous plaque control is recommended for treatment of gingival overgrowth. Substitution of the drug or surgical procedures such as gingivectomy and periodontal flaps should be considered after re-evaluation. Azithromycin is often recommended as a supplementary drug to reduce this side effect. Recent studies show that tacrolimus can be a more economic, efficient and safe substitute for CsA.
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KEYWORD
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Cyclosporine, Gingival overgrowth, Organ transplantation, Tacrolimus
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